Synthesis of highly substituted oxazoles through iodine(III)-mediated reactions of ketones with nitriles.
نویسندگان
چکیده
In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf₂NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.
منابع مشابه
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ورودعنوان ژورنال:
- Molecules
دوره 17 9 شماره
صفحات -
تاریخ انتشار 2012